Clinical Decision Support (CDS) refers broadly to providing clinicians or patients with clinical knowledge and patient-related information, intelligently filtered or presented at appropriate times, to enhance patient care. Clinical knowledge of interest ranges from simple facts and relationships to best practices for managing patients with specific disease states, new medical knowledge from clinical research and other types of information. Delivering one or more specific pieces of clinical knowledge to an individual at a specific time requires both the right content and the appropriate logistics. There are different types of CDS interventions: templates, proactive order sets, guidelines, protocols, templates and reference information. This seminar will focus on integration of reference information into the workflow of clinicians at the point of care. Examples will illustrate methods, barriers, developing standards and other implementation issues using examples drawn from the University of Washington and opportunities at Stanford.