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STRIDE (Stanford Translational Research Integrated Database Environment)
is an informatics research and development project at
Stanford University Medical Center (SUMC) to create a
HIPAA-compliant biomedical data repository based on emerging
informatics standards. The overall goals of the project
are to provide a standards-based research data management
service to the SUMC community and to create a clinical
data warehouse that supports SUMC's clinical and translational
research mission. The STRIDE project is based in the
Stanford Center for Clinical Informatics, within the Office
of Information Resources and Technology (IRT) at
Stanford University School of Medicine.
From a technology and standards perspective, STRIDE
is hosted on the Oracle
10G database platform. The STRIDE data model is based
on the Health
Level Seven (HL7) Reference Information Model (RIM),
an object-oriented model of biomedical information that
is designed to support interoperability. STRIDE uses
SNOMED CT and the National
Library of Medicine's Unified Medical Language System
(UMLS) as its internal semantic model for biomedical
data representation, thus ensuring semantic interoperability
with local and national databases, including SUMC's Electronic
Health Record. STRIDE also incorporates a clinical document
representation system based on the HL7
Clinical Document Architecture (CDA) model that,
combined with a natural language parser, automatically
identifies embedded biomedical concepts, mapping them
to standard biomedical terminologies.
STRIDE receives clinical data for research use via HL7
feeds from both SUMC hospitals: Lucile Packard Children's
Hospital and Stanford Hospital and Clinic. This clinical
data is used to support a wide variety of translational
research projects including: Anonymized Patient Research
Cohort Discovery, Electronic Chart Review for Research,
IRB-Approved Clinical Data Extraction, Tissue Banking,
Multimedia Research Data Management and Research Registries.
STRIDE is a highly secure environment utilizing encryption,
fine-grained access control, robust auditing and detailed
data segregation. Additionally, STRIDE has a robust access
control framework with well-defined access granting authorities
and access control groups. Consequently STRIDE meets
or exceeds the requirements of the HIPAA Privacy and
Security regulations. Privacy protection is further enhanced
by requiring IRB approval for all research projects using
STRIDE clinical data.
STRIDE applications software provide access to the J2EE
services of a three-tier infrastructures using SSL encryption
with strong authentication. These programs are cross-platform,
self-updating thick-client applications that provides
a rich user interface for data entry, retrieval and review
as well as image manipulation and annotation. STRIDE
makes extensive use of XML technologies for representation
of structured meta data, distributed systems technologies
using enterprise java beans (EJB) for secure remote communication
between client and server, and Swing graphical interface
components providing a rich widget-set as well as advanced
imaging and graphing capabilities. Users of the STRIDE
Research Desktop Client can perform rapid data entry
into structured fields, compose complex queries, and
interact securely with clinical, research and imaging
data. |
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